Wounds and inflammation
Our bodies have developed a complex and highly evolved innate response to facilitate the repair of damaged tissue. This response, mediated by numerous immune and non-immune cells, involves complex cascades of cytokines and growth factors. Within the Manchester Immunology Group we employ in vitro, in vivo and clinical studies aimed at indentifying and characterising key factors in tissue repair. We have a particular interest in skin wound healing. Chronic non-healing skin wounds represent a major area of unmet clinical need, leading to high levels of morbidity and mortality. A key correlate to pathological healing is excessive inflammation. By understanding the role of inflammatory mediators, and microbial sensing in delayed repair we should be able to develop improved treatments for this debilitating problem.