Immunogenetics is the study of the role of genetic variation in the immune response. There are two main aspects to this work in Manchester. Firstly we are using mapping experiments to determine the role of host genetics in susceptibility to infectious disease. We are finding striking similarities between the response to infection in the gut and human Crohn’s disease. Secondly, we are using sophisticated in vivo genetic knockout technology to investigate the role of specific genes in different cell types. This work is very exciting as it enabling discreet dissection of the immune response not previously possible. Contact us for more information.