I obtained a BSc (Hons) in Genetics from the University of York, during which I spent an industrial year working at the Royal Botanic Gardens, Kew London. Following this I undertook my PhD in the lab of Adrian Mountford at the University of York focusing on how helminth infection skews immune events in the skin. After completing my PhD in 2009, I trained as a post doc at the University of Edinburgh with Andrew MacDonald investigating the impact of type-2 immunity on innate cells, particularly DCs. I relocated with the laboratory to the Manchester Collaborative Centre for Inflammation Research (MCCIR) in 2013 and discovered novel mechanisms by which DCs utilise to drive allergic type-2 inflammation. In 2016 I was awarded the Dean’s Prize to help establish a research group to unravel why exposure to fungi in the airways causes immune cells to mediate chronic allergic inflammation.
Cook, P.C. and MacDonald A.S. Dendritic cells in lung immunopathology. Semin Immunopathol. 2016, 38(4): 449-460.
Cook, P.C., Owen, H., Deaton, A.M., Borger, J.G., Brown, S.L., Clouaire, T., Jones, G-R., Jones, L.H., Lundie, R.J., Marley, A.K., Morrison, V.L., Phythian-Adams, A.T., Wachter, E., Webb, L.M., Sutherland, T.E., Thomas, G.D., Grainger, J.R., Selfridge, J., McKenzie, A.N.J., Allen, J.E., Fagerholm, S.C., Maizels, R.M., Ivens, A., Bird, A., and MacDonald, A.S. A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.Nat. Commun. 2015, 6:6920.
Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., and MacDonald, A.S. Alternatively activated dendritic cells regulate CD4+ T cell polarization in vitro and in vivo. PNAS 2012, 109: 9977-9982.
Jenkins, S.J., Ruckerl, D., Cook, P.C., Jones, L.H., Finkelman, F.D., van Rooijen, N., MacDonald, A.S. and Allen, J.E. Local macrophage proliferation, rather than recruitment from the blood, is a signature of Th2 inflammation. Science. 2011, 332: 1284-1288.
Cook, P.C., Aynsley, S.A., Turner, J.D., Jenkins, G.R., Van Rooijen, N., Leeto, M., Brombacher, F., and Mountford, A.P. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathogens. 2011, 7(3):e1001323.