Dr Peter Arkwright

Peter Arkwright research summary

Peter Arkwright

Peter Arkwright

Biography

  • Sir Robert Menzies Memorial Scholar in Medicine, D Phil – University of Oxford, 1985 – 1989
  • Beit Memorial Research Fellow, University of Oxford, 1989 – 1992
  • Clinical Lecturer/Hon Senior Registrar, Paediatrics, University of Manchester, 1996 – 2002
  • Senior Lecturer/Hon Consultant, Paediatric Allergy, Immunology & Infectious Diseases, The University of Manchester, 2002 – present

Memberships of committees and professional bodies

  • Fellow of the Royal College of Paediatrics and Child Health
  • International Fellow of the American Academy of Allergy, Asthma and Immunology
  • Member of the European Society for Immunodeficiencies
  • Member of the UK Primary Immunodeficiency Network

Qualifications

  • MB BS, University of Western Australia, graduated 1984
  • D Phil, Oxford University, graduated 1989
  • MRCPCH 1994
  • FRCPCH 2004

Research interests

Primary Immunodeficiency Diseases (PID):

  • molecular and cellular basis (specific antibody deficiency, CVID, ALPS, APECED syndrome, HLH)
  • genotype – phenotype correlations
  • development of novel treatments for PID and its complications

Atopic Diseases – particularly atopic dermatitis:

  • genetic and environmental factors
  • role of Staphylococcus aureus in triggering skin inflammation
  • use of immunosuppressants in children with severe atopic dermatitis
  • psychological impact on the family

Social responsibility

  • PID UK, Medical Advisory Panel
  • Anaphylaxis Campaign, Healthcare Professional member
  • North West Paediatric Allergy Network, Chair
  • Royal College of Paediatrics and Child Health, Council Representative for North West
  • NHS England North West – ACF program academic lead
  • Journal of Allergy & Clinical Immunology, Member of Editorial Board

Teaching

  • MSc Immunology – Clinical Immunology
  • Post-doctoral research teaching at MSc, MRes, MD and PhD level
  • MB BS medical student advisor
  • MB BS project option supervisor
  • MB BS OSCE examiner

Collaborators

Local

Professor Silvia Bulfone-Paus
Professor Tracy Hussell
Dr Cath O'Neill
Dr Joanne Pennock
Dr Guoqing Xia

National & International

Professor Jean-Laurent Casanova, New York
Professor Sophie Hambleton, Newcastle upon Tyne
Professor Christoph Klein, Hannover
Dr Sylvain Latour, Paris
Professor Hiroshi Matsuda, Tokyo
Dr Joshua Milner, Washington, DC
Dr Anne Puel, Paris
Dr Frederic Rieux-Laucat, Paris
Professor Akane Tanaka, Tokyo
Professor Stuart Tangye, Sydney

Collaborators

Local

Professor Silvia Bulfone-Paus
Professor Tracy Hussell
Dr Cath O'Neill
Dr Joanne Pennock
Dr Guoqing Xia

National & International

Professor Jean-Laurent Casanova, New York
Professor Sophie Hambleton, Newcastle upon Tyne
Professor Christoph Klein, Hannover
Dr Sylvain Latour, Paris
Professor Hiroshi Matsuda, Tokyo
Dr Joshua Milner, Washington, DC
Dr Anne Puel, Paris
Dr Frederic Rieux-Laucat, Paris
Professor Akane Tanaka, Tokyo
Professor Stuart Tangye, Sydney

Biography

Peter Arkwright trained in medicine at the University of Western Australia, collating with a BMedSci (Hon). He was awarded one of three national Sir Robert Menzies Memorial Scholarships, which allowed him to complete a D Phil and then a Beit Memorial Research Fellowship in the Departments of Obstetrics & Gynaecology, University of Oxford from 1985 - 1993. His area of interest was reproductive immunology and glycobiology. He then completed his paediatric / paediatric allergy, infectious disease and immunology training rotating between Birmingham, Southampton, London, Newcastle and Manchester UK. Since 2002 he has had a joint appointment at the University of Manchester and Central Manchester Foundation Trust. He has published 140 peer-reviewed publications. His diverse interests include atopic dermatitis, anaphylaxis, primary immunodeficiency diseases with a focus on translating basic science into clinical practice. Dr Arkwright coordinated the setting up of the current paediatric allergy and immunology services in the North West of England. He chairs the North West Paediatric Allergy Network and leads their Future Hospital Initiative with the Royal College of Physicians. He is the North West Representative for the RCPCH and is not the Editorial Board of the Journal of Allergy & Clinical Immunology.

Selected publications

  • Lyons J, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi N, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum typtase identifies a multisystem disorder associated with increased α tryptase copy number. Nat Genet. 2016 Oct 17.
  • Jang J, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim S-H, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model. J Invest Dermatol, 2016;136:127-35.
  • Martin E, Palmic N, Hauck F, Lenior C, Fabrega S, Nitschke P, Mongellaz C, Degli Esposti M, Taylor N, Picard C, Majewski J, Jabado N, Wynn R, Fischer A, Arkwright PD*, Latour S*. Inherited CTP synthase 1 deficiency in humans reveal a central role of CTPS1 induction in proliferation of activated T lymphocytes. Nature 2014,May 28 (*joint senior authors).
  • Bewick DC, Wright NB, Pumphrey RS, Arkwright PD. Anatomical and anthropometric determinants of intramuscular versus subcutaneous administration in children with epinephrine auto-injectors. J Allergy Clin Immunol In Practice 2013;1:642-4.
  • Subbarayan A, Colarusso G, Hughes SM, Gennery AR, Slatter M, Cant AJ, Arkwright PD. Clinical features that identify children with primary immunodeficiency diseases. Pediatr 2011;127:810-6.
  • Ng F, Delwig A, Carmichael AJ, Arkwright PD, Abinun M, Cant AJ, Jolles S, Lilic D. Impaired Th-17 responses in patients with chronic mucocutaneous candidiasis with and without APECED. J Allergy Clin Immunol 2010;126:1006-15. (Editors choice)
  • Santer DM, Hall BE, George TC, Tangsombatvisit C, Liu CL, Arkwright PD, Elkon KB. C1q deficiency leads to the defective suppression of IFN-a in response to nucleoprotein containing immune complexes. J. Immunol. 2010;185:4738-49. (Editors’ choice)
  • Summers CW, Pumphrey RS, Woods CN, McDowell G, Pemberton P, Arkwright PD. Clinical and laboratory parameters predicting the nature and severity of allergic reaction after ingestion of nuts. J Allergy Clin Immunol 2008;121:632-8. (Editors’ choice)
  • Arkwright PD, Abinun M, Cant AJ. Mevalonic aciduria cured by bone marrow transplantation. N Engl J Med 2007;357:1350.
  • Chapgier A, Wynn RF, Jouanguy E, Filipe-Santos O, Zhang S, Feinberg J, Hawkins K, Casanova JL, Arkwright PD. Human complete Stat-1 deficiency is associated with defective type I and II interferon responses in vitro but immunity to some low virulence viruses in vivo. J Immunol 2006;176;5078-83.
  • Wynn RF, Arkwright PD, Haque T, Gharib MI, Wilkie G, Morton-Jones M, Crawford DH. Allogeneic EBV-specific cytotoxic T lymphocyte infusions are effective in the treatment of EBV-driven primary CNS lymphoma. Lancet Oncology 2005;6:344-6.
  • Holzelova E, Vonarbourg C, Stolzenberg M-C, Arkwright PD, Selz F, Prieur A-M, Blanche S, Bartunkova J, Vilmer E, Fischer A, Le Deist F, Rieux-Laucat F. Autoimmune lymphoproliferative syndrome (ALPS-III) caused by somatic mutations of TNFRSF6 (fas). New Engl J Med 2004;351:1409-18. (commentary pp1389-90)
  • Rafatpanah H, Bennett E, Pravica V, McCoy MJ, David TJ, Hutchinson IV, Arkwright PD. Inheritance of a specific GM-CSF genotype is associated with complete protection against severe atopic dermatitis. J. Allergy Clin Immunol. 2003;112:593-8 (Editors choice)
  • Arkwright PD, Pravica V, Geraghty PJ, Super M, Webb AK, Schwarz M, Hutchinson . End-organ dysfunction in cystic fibrosis: association with ACE and cytokine gene polymorphisms. Am J. Respir Crit Care Med 2003;167:384-9 (Editor’s choice)
  • Arkwright PD, Rademacher TW, Dwek RA, Redman CW. Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles. Journal of Clinical Investigation 1993;91:2744-2753.
  • Arkwright PD, Beilin LJ, Vandongen R, Rouse I, Lalor C. The pressor effect of moderate alcohol consumption in man. A search for mechanisms. Circulation 1982;66:515-519.