Dr Pawel Paszek

Pawel Paszek – Research summary

Dr Pawel Paszek

Dr Pawel Paszek

Biological complexity – new way to understand inflammation

Our group is interested in dynamical cellular and molecular networks that regulate activation and resolution of inflammation. These networks exemplify inherent complexity of biological signalling systems associated with different level of cellular organisations and stochastic dynamics.

We are using interdisciplinary systems biology approach including state-of-the-art mathematical modelling, live-cell microscopy (with microfluidics) and quantitative assays for gene expression. We are interested in dynamics and function of regulatory networks involving NF-kappaB, STATs and interferons, in control of macrophage and T-cell activation, differentiation and plasticity. Our aim is to resolve how inflammatory responses in cells and tissues are regulated in space and time. A more quantitative understanding of these non-linear and non-intuitive processes might lead to improved therapeutic strategies for inflammatory disease.

Email: pawel.paszek@manchester.ac.uk Tel: 0161 275 1743

People

Pawel Paszek – People

Dr James Bagnall
Lorraine Schmidt
Ruth Brignall (PhD student)
Chris Boddington (PhD student)
Hazel England (Post-Doc)

Past Group Members

Simon Mathers, MSc Immunology
Varvara Sousanidou, Erasmus visiting student

People

Pawel Paszek – People

Dr James Bagnall
Lorraine Schmidt
Ruth Brignall (PhD student)
Chris Boddington (PhD student)
Hazel England (Post-Doc)

Past Group Members

Simon Mathers, MSc Immunology
Varvara Sousanidou, Erasmus visiting student

Biography

I am a BBSRC David Phillips Research Fellow in the Immunology Research Group in the Faculty of Biology, Medicine and Health.

I am a theoretician by background (M.S. in Automatic Control, Ph.D. in Statistics), but for the past several years I have been combining systems biology approaches to understand regulation of immune signaling networks. In my post-doctoral position I was leading theory work and experimental design in an interdisciplinary team in Centre for Cell Imaging in Liverpool and investigated temporal dynamics and function of the NF- kappaB, a pivotal transcription factor governing the immune response. In 2011 I received a BBSRC David Phillips Fellowship and joined the Immunology Research Group in Manchester.

Publications

  • Paszek, P., Jackson, D. & White, M (2010). Oscillatory control of signalling molecules. Curr Opin Genet Dev, 20(6), 670-6.
  • Paszek, P., Ryan, S., Ashall, L., Sillitoe, K., Harper, C., Spiller, D., Rand, D. & White, M (2010). Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci U S A, 107(25), 11644-9.
  • *Ashall, L., *Horton, C., *Nelson, D., *Paszek, P., Harper, C., Sillitoe, K., Ryan, S., Spiller, D., Unitt, J., Broomhead, D., Kell, D., Rand, D., Sée, V. & White, M (2009). Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science, 324(5924), 242-6. (* Joint first authors)
  • Paszek, P (2007). Modeling stochasticity in gene regulation: characterization in the terms of the underlying distribution function. Bull Math Biol, 69(5), 1567-601