Prof Kathryn Else

Kathryn Else – Research summary

Kathryn Else

Kathryn Else

I am a Professor of Immunology with a particular interest in parasite immunology.

My research group studies the cellular immune responses to gastrointestinal dwelling nematode parasites, focussing on the mechanisms of immunity to Trichuris muris and the mechanisms which regulate the intestinal inflammation induced by infection. We are particularly interested in the cellular events which occur locally at the site of infection and understanding how local stimulation of the innate immune system to precipitate worm expulsion is integrated with anti-inflammatory signals to avoid host damaging immunopathology. This latter interest incorporates studies on colonic macrophages and their different activation states. We are also very interested in trying to understand the mechanisms by which vaccination protects against worms and the influence of time of day of vaccination on vaccine efficacy. As part of our work on mechanisms to control infection we have a focus on identifying parasite derived immunomodulatory molecules as potential lead candidates in vaccine development, and a project exploring new drugs to control whipworm infection.

KEY WORDS: inflammation, mucosal immunity, macrophages, vaccination, Intestinal nematode parasites, circadian biology

Email: kathryn.j.else@manchester.ac.uk | Tel: 0161 275 5213 | Twitter: @kathelse

People

Kathryn Else – People

Munirah Albaqshi (PhD Student)
Dr Ruth Forman
Maria Glymenaki
Dr Matthew C. Little
Emma Murphy (PhD student)
Rinal Sahputra (PhD student)
Hannah Smith

Past lab members

Post Doctoral Research Associates and Research Fellows
Catherine Betts
David Artis
Jackie McDermott
Renu Datta
Marcus Svensson
Matthew deSchoolmeester
Becky Hurst
Louise Bell

PhD students
Matthew Taylor
Nathan Blackwell
Emily Rice
Claire Johnston
Sarah Otto
Cornelia Hedeler
Lianne Harlow
Helen Dixon
Riccardo d’Elia

People

Kathryn Else – People

Munirah Albaqshi (PhD Student)
Dr Ruth Forman
Maria Glymenaki
Dr Matthew C. Little
Emma Murphy (PhD student)
Rinal Sahputra (PhD student)
Hannah Smith

Past lab members

Post Doctoral Research Associates and Research Fellows
Catherine Betts
David Artis
Jackie McDermott
Renu Datta
Marcus Svensson
Matthew deSchoolmeester
Becky Hurst
Louise Bell

PhD students
Matthew Taylor
Nathan Blackwell
Emily Rice
Claire Johnston
Sarah Otto
Cornelia Hedeler
Lianne Harlow
Helen Dixon
Riccardo d’Elia

Publications

Little MC, Hurst RJ, Else KJ. Dynamic Changes in Macrophage Activation and Proliferation during the Development and Resolution of Intestinal Inflammation. J Immunol. 2014 Nov 1;193(9):4684-95.

Hurst RJ, Hopwood T, Gallagher AL, Partridge FA, Burgis T, Sattelle DB, Else KJ. An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro.BMC Infect Dis. 2014 Sep 27;14(1):520. [Epub ahead of print]

Thagia I, Smith E, Shaw E, Else KJ and Rigby RJ. Intestinal Epithelial Suppressor of Cytokine Signalling (SOCS) 3 Enhances Microbial Induced Inflammatory TNFα, contributing to epithelial barrier dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology 2014 Nov 6:ajpgi.00214.2014. doi: 10.1152/ajpgi.00214.2014.

Hurst RJM, Bell LV, Little MC, de Caul A,  Kagechika H and Else KJ. The Retinoic Acid Receptor agonist AM80 increases mucosal inflammation during an intestinal helminth infection of mice. Journal of Clinical Immunology 2013 33(8):1386-94

Hurst RJM and Else KJ. The retinoic acid producing capacity of gut dendritic cells and macrophages is reduced during persistent T. muris infection Parasite Immunology, 2013 Jul;35(7-8):229-33.

Forman R, deSchoolmeester ML, Hurst RMJ, Pemberton A, Wright S and Else KJ. The Goblet Cell is the Cellular Source of the Anti-microbial Angiogenin 4 in the Large Intestine Post Trichuris muris infection. PLoS One. 2012;7(9):e42248.

Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS. The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7. Epub 2011 Dec 19

Bowcutt R, Bell LV, Little M, Wilson J, Booth C, Murray P., Else KJ, Cruickshank SM. Arginase-expressing macrophage play no role in the expulsion of Trichuris muris or in the regulation of pathology. Parasite Immunol. 2011 Jul;33(7):411-20.

Svensson, M., Russell K, Mack M and Else KJ (2010) CD4+ T cell localization to the large intestinal mucosa during Trichuris muris infection is mediated by Gai-coupled receptors but is CCR6- and CXCR3-independent. Immunology 129, 257–267

Dixon H., Little MC., and Else KJ. (2010) The protective Th2 response following subcutaneous vaccination against T. muris. International Journal for Parasitology 2010 May;40(6):683-93.

d’Elia R, Deschoolmeester M, Zeef L, Wright SH, Pemberton AD, Else KJ. (2009) Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell. BMC Genomics 10:492.

d’Elia R., Behnke JM, Bradley JE., and Else KJ. (2009) Regulatory T cells: a role in intestinal helminth survival and the control of host pathology. Journal of Immunology 182, 2340-2348.

Cruickshank SM, Deschoolmeester M, Svensson M, Bazakou A, Logunova L, Little MC, Howell G, English N, Grencis RK, Else KJ*, Carding SR*. (2009) Epithelial cells mediate rapid Colonic Dendritic Cells responses to Trichuris muris Infection in Resistant but not Susceptible Mice. Journal of Immunology 182: 3055–3062)(*joint senior authors).

deSchoolmeester ML., Martinez Pomares L., Gordon S and Else KJ. (2009) The mannose receptor is not important in the expulsion of Trichuris muris. Immunology 126(2), 246-55. Epub 2008 Jun 27

Biography

I obtained a first class honours degree in Zoology in 1985 at the University of Nottingham. I was awarded a Post Graduate Certificate in Education in 1986 and completed my PhD, also at the University of Nottingham, in 1989 focussing on aspects of immunity to intestinal nematode parasites. I continued to pursue my interest in parasite immunology at the University of Manchester, first as an MRC post-doctoral training fellow (1989) then a Wellcome Trust Fellow (1992) before becoming a Wellcome Trust Senior Research Fellow in Basic Biomedical Science in 1995. I became a Senior Lecturer in 2007 and Professor of Immunology in 2009.

See my Faculty profile for more information.