Dr Adam Hurlstone

Adam Hurlstone – Research summary

Dr Adam Hurlstone

Dr Adam Hurlstone

Understanding host immune responses to melanoma

Immune cells comprise a significant component of the melanoma tumour microenvironment. While the host can generate immunity to transformed melanocytes, negating their threat, clones can emerge that evade and/or suppress immune rejection. Furthermore, immune cells can abet cancer metastasis through the production of growth and survival factors, proteases and chemokines. My group is using zebrafish to investigate the immune response to melanoma and to gain insight into the switch from immunity to treachery. To assist this effort, we have created transgenic reporter lines to visualize dendritic cells, macrophages and T lymphocytes in the tumour microenvironment, mutations in critical immunoregulatory molecules, and vector systems for misexpressing immunoregulatory factors in immune cells as well as in melanoma cells.

Email: adam.hurlstone@manchester.ac.uk | Tel: 0161 275 1574 | Faculty profile: Dr Adam Hurlstone

People

Adam Hurlstone – People

Helen Young (PhD student)
Raghavender Nagaraju (PhD student)
Dr Christopher Dee (PDRA)

People

Adam Hurlstone – People

Helen Young (PhD student)
Raghavender Nagaraju (PhD student)
Dr Christopher Dee (PDRA)

Collaborators

Prof Paul Martin, Bristol University
Dr Stephen Renshaw, University of Sheffield
Prof Chris Secombes, University of Aberdeen

Biography

I received my bachelor degree from Cambridge in 1994 and a PhD from the Beatson Institute for Cancer Research, Glasgow in 1998. I trained as a post-doctoral research associate in the Hubrecht Institute, Utrecht, the Netherlands under the guidance of Prof Hans Clevers. I became an independent fellow at the University of Manchester, Faculty of Life Sciences in 2004 and am now a senior lecturer in the School of Medical Sciences.

Publications

  • Dalton L, Kamarachev J, Barinaga-Rementeria Ramirez I, White G, Malliri A and Hurlstone A. Constitutive Rac activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Journal of Investigative Dermatology 2013 Jun;133(6):1572-81.
  • Haud N, Kara F, Diekmann S, Henneke M, Willer JR, Hillwig MH, Gregg RB, MacIntosh GC., Gärtner J, Alia A, and Hurlstone A. rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc Natl Acad Sci USA 2011 Jan 18;108(3):1099-103.
  • Feng Y, Santoriello C, Mione M, Hurlstone A, and Martin P. Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biology 2010 Dec 14;8(12), e1000562.
  • Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty K, and Lawson ND. microRNA-mediated integration of mechanosensation and Vegf signaling during angiogenesis. Nature. 2010 Apr 22;464(7292):1196-200.
  • Michailidou C, Jones M, Walker P, Kamarashev J, Kelly A, and Hurlstone A. Dissection of the roles of Raf- and PI3k-signalling pathways in melanoma formation and progression in an in vivo zebrafish model. Disease Models and Mechanisms, 2009 Jul-Aug; 2(7-8):399-411.